MovDisordV3, Main, Exploration, bibRecord, 001864

Systematic Genetic Analysis of the PITX3 Gene in Patients with Parkinson Disease

Identifieur interne : 001864 ( Main/Exploration ); précédent : 001863; suivant : 001865

Systematic Genetic Analysis of the PITX3 Gene in Patients with Parkinson Disease

Auteurs : YI GUO [République populaire de Chine] ; Wei-Dong Le [États-Unis] ; Joseph Jankovic [États-Unis] ; Hua-Rong Yang [République populaire de Chine] ; Hong-Bo Xu [République populaire de Chine] ; Wen-Jie Xie [États-Unis] ; ZHI SONG [République populaire de Chine] ; HAO DENG [République populaire de Chine, États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0380309

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Human, Nervous system diseases, Parkinson disease.

Abstract

Background: Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons. Methods: To determine whether genetic variation in the coding region of the paired-like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease. Results: We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early-onset Parkinson's disease and familial Parkinson's disease.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons. Methods: To determine whether genetic variation in the coding region of the paired-like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease. Results: We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early-onset Parkinson's disease and familial Parkinson's disease.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Systematic Genetic Analysis of the PITX3 Gene in Patients with Parkinson Disease

Systematic Genetic Analysis of the PITX3 Gene in Patients with Parkinson Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri